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Research Archive

124 indexed research and patent records on Aureobasidium pullulans beta glucan. Each entry includes available bibliographic details, a summary, and source identifiers.

124
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Records
28
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Indexed
40+
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124 studies found
In Vitro 2025

Antibacterial and antioxidant activities of β-glucans derived from Aureobasidium pullulans

Three A. pullulans beta-glucan fractions were compared in laboratory assays.
Food Bioscience DOI: 10.1016/j.fbio.2025.107074
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Review 2025

Beta (β)-glucan as Microbial Polymer with Nutraceutical Potential

A narrative review of microbial beta-glucan chemistry, production, and nutraceutical uses.
Microbial Nutraceuticals DOI: 10.1002/9781394241538.ch11
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Review 2025

Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting

β-Glucans activate macrophages, NK cells, and dendritic cells via Dectin-1, TLRs, and CR3, creating a potent anti-tumor immune environment.
Naunyn-Schmiedeberg's Archives of Pharmacology DOI: 10.1007/s00210-025-04519-8 PMID: 40864254
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RCT 2025

Efficient Control of IL-6, CRP and Ferritin in COVID-19 Patients With Two Variants of Beta-1,3-1,6 Glucans in Combination: An Open-Label, Prospective, Randomised Clinical Trial

Forty COVID-19 patients received standard care with or without two AP-beta-glucans.
Global Advances in Integrative Medicine and Health DOI: 10.1177/27536130251327134 PMID: 40092217
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Review 2025

Involvement of β-glucan receptors on the antitumor activity of β-glucans

The review discusses Dectin-1, CR3, and other beta-glucan recognition pathways.
Clinical Immunology Communications DOI: 10.1016/j.clicom.2024.12.002
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Patent 2025

Thailand Patent No. 76798

Thailand Patent No. 76798 protects AP β-glucan health applications in Thai market.
Thai Department of Intellectual Property
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In Vivo 2025

β-Glucan induced plasma B cells differentiation to enhance antitumor immune responses by Dectin-1

β-Glucan promotes plasma B cell differentiation via Dectin-1, boosting antibody production and enhancing adaptive antitumor immune responses.
BMC Immunology DOI: 10.1186/s12865-025-00681-z PMID: 39794756
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In Vitro 2024

Melanin Synthesized by the Endophytic Aureobasidium pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity

A. pullulans AKW synthesized 4.89 g/L melanin via a novel tyrosine-independent pathway in simple fermentation medium.
Current Topics in Medicinal Chemistry DOI: 10.2174/0115680266300091240730111333 PMID: 39161142
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Review 2024

Potential promising anticancer applications of β-glucans: a review

The review surveys proposed antitumor mechanisms and applications of beta-glucans.
Bioscience Reports DOI: 10.1042/bsr20231686
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In Vitro 2023

5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells

5-Demethylnobiletin induces cancer cell cycle arrest and apoptosis in treated cells.
Frontiers in Oncology DOI: 10.3389/fonc.2023.1143664
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Review 2023

Aureobasidium spp.: Diversity, Versatility, and Agricultural Utility

Aureobasidium species are diverse fungi with several agricultural and food-related applications.
Horticulturae DOI: 10.3390/horticulturae9010059
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RCT 2023

Benefits of Gut Microbiota Reconstitution by Beta 1,3–1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases

AFO-202 AP-beta-glucan improved behavior, sleep quality, and melatonin levels in Parkinson's disease patients
Journal of Alzheimer's Disease DOI: 10.3233/JAD-220388 PMID: 36093695
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Patent 2023

Bio-healing agent – Taiwan (Taiwan Patent No. I364284)

Taiwan patent (No. I364) protects AP β-glucan as bio-healing agent.
Taiwan Intellectual Property Office
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Patent 2023

Bio-healing agent-China (China Patent No. ZL200780040329.9)

China patent protects AP β-glucan as bio-healing agent (Patent ZL20078004).
China National Intellectual Property Administration
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Patent 2023

Bio-healing agent-Hong Kong (Hong Kong License No. HK1136492)

Hong Kong license protects AP β-glucan bio-healing agent applications.
Hong Kong Intellectual Property Department
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Patent 2023

Biological healing accelerator – Japan (License No. 5331482)

AP β-glucan demonstrated biological healing acceleration, potentially through macrophage-mediated repair.
Japanese Patent Office
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Patent 2023

Biological healing accelerator – Japan (Patent No. 5715659)

Japanese patent for AP β-glucan as biological healing accelerator.
Japanese Patent Office
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Patent 2023

Biological healing accelerator-EU (European Patent No. 2098240)

EU patent protects AP β-glucan as biological healing accelerator.
European Patent Office
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Patent 2023

Biological healing accelerator-EU (European Patent No. 2630961)

European patent record describing a claimed biological healing accelerator.
European Patent Office
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Patent 2023

Composition containing β-glucan and constipation ameliorant, immunostimulant and skin moisturizer using the composition – China (China Patent No. ZL200480001038.5)

Patent covers β-glucan composition and associated constipation improvement claims.
Japanese Patent Office
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Patent 2023

Composition containing β-glucan and constipation-improving agent, immunostimulant and skin moisturizer using the composition – EU (European Patent No. 1602377)

AP β-glucan composition combines constipation relief (prebiotic) and immune enhancement in one formulation.
Japanese Patent Office
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Patent 2023

Composition containing β-glucan, constipation-improving agent using the composition, immunostimulant, and skin moisturizer – Taiwan (Taiwanese Patent Invention No. I282279)

β-glucan composition with constipation-improving and immune-enhancing application.
Japanese Patent Office
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Patent 2023

Composition containing β-glucan, method for producing the same, and food or beverage or skin moisturizer containing the composition – Hong Kong (HK Patent No. HK1109426)

Japanese patent protects specific AP β-glucan-containing compositions and production methods.
Japanese Patent Office
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Patent 2023

Composition containing β-glucan, method for producing the same, and food or drink or skin moisturizer containing the composition – Korea (Korean Patent No. 10-0961055)

AP β-glucan composition and production method patent for health product formulation.
Japanese Patent Office
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Patent 2023

Composition for enhancing the efficacy of antibody drugs – Japan Patent No. 7088502

Japanese patent protects AP β-glucan compositions for enhancing antibody therapeutic efficacy via ADCC.
Japanese Patent Office
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Patent 2023

Composition for prevention and treatment of bovine mastitis and method for prevention and treatment of bovine mastitis – Japan (Patent No. 5554221)

Japanese patent record concerning a claimed composition and method for bovine mastitis.
Japanese Patent Office
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Patent 2023

Compositions for promoting hematopoietic function and for preventing and/or improving anemia – Japan (Patent No. 6293187)

AP β-glucan promotes hematopoietic function, stimulating immune cell production in bone marrow.
Japanese Patent Office
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Patent 2023

Compositions promoting cytokine production in macrophages – Japan (Patent No. 5559173)

Japanese patent protects compositions for promoting macrophage cytokine production using AP β-glucan.
Japanese Patent Office
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Patent 2023

Constipation-improving agent – Japan (Patent No. 4054697)

AP β-glucan demonstrates constipation-improving properties through prebiotic fiber and gut motility effects.
Japanese Patent Office
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Patent 2023

Cytokine production enhancing compositions in macrophages – U.S. (U.S. Patent No. US8,802,433)

Japanese patent protects AP-glucan formulations specifically for enhancing macrophage cytokine production.
Japanese Patent Office
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In Vitro 2023

Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells

Chondroitin sulfate preparations were compared in two murine cell models.
PLOS ONE DOI: 10.1371/journal.pone.0284343
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Clinical 2023

Efficacy of N-163 beta-glucan in beneficially improving biomarkers of relevance to muscle function in patients with muscular dystrophies in a pilot clinical study

Pilot clinical study evaluating N-163 beta-glucan and biomarkers or measures relevant to muscle function in muscular dystrophy.
Acta Myologica DOI: 10.36185/2532-1900-312 PMID: 38406382
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Patent 2023

Fat accumulation inhibitor – Japan (Patent No. 6380968)

AP β-glucan demonstrated fat accumulation inhibitory properties in Japan patent claims.
Japanese Patent Office
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Patent 2023

Immune adjuvant – Japan (Patent No. 5242855)

Japanese patent claims AP β-glucan as an immune adjuvant enhancing vaccine and immune therapy responses.
Japanese Patent Office
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Patent 2023

Immunity Enhancer – Japan (License No. 4369258)

Japanese patent protects AP-glucan immunity-enhancing compositions and formulation methods.
Japanese Patent Office
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In Vivo 2023

Low-Molecular-Weight β-1,3-1,6-Glucan Derived from Aureobasidium pullulans Exhibits Anticancer Activity by Inducing Apoptosis in Colorectal Cancer Cells

In BALB/c mice bearing CT-26 tumors, LMW-AP-FBG given for two weeks reduced tumor growth versus buffer-treated controls.
Biomedicines DOI: 10.3390/biomedicines11020529 PMID: 36831065
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Patent 2023

Moisturizer for skin – Japan (Patent No. 4000078)

Japanese patent protects AP β-glucan as a skin moisturizer based on hygroscopic and anti-inflammatory properties.
Japanese Patent Office
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Patent 2023

Probes for observation of intestinal post-absorptive kinetics using beta-1,3-1,6 glucan labeled with stable isotope 2H and/or stable isotope 13C – Japan (Patent No. 5360849)

AP β-glucan developed as probe compound for studying intestinal absorption and post-absorptive distribution.
Japanese Patent Office
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Patent 2023

Therapeutic agent for influenza virus infection – Japan (Patent No. 5560472)

Japanese patent claims AP β-glucan as a therapeutic for influenza through innate antiviral immune enhancement.
Japanese Patent Office
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Patent 2023

Therapeutic agent for influenza virus infection – Taiwan (Taiwan Patent Invention No. I496578)

Japanese patent claims AP β-glucan as therapeutic agent for influenza virus infection.
Japanese Patent Office
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Patent 2023

TRAIL expression enhancer – Japan (Patent No. 5937029)

AP β-glucan enhances TRAIL expression in immune cells, enabling selective cancer cell killing.
Japanese Patent Office
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In Vitro 2023

Transcriptome Analysis Reveals the Regulation of Aureobasidium pullulans under Different pH Stress

Transcriptome analysis identified key genes regulating β-glucan biosynthesis in A. pullulans.
International Journal of Molecular Sciences DOI: 10.3390/ijms242216103
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Review 2023

Utilization of Food-Derived β-Glucans to Prevent and Treat Non-Alcoholic Fatty Liver Disease (NAFLD)

Food-derived β-glucans, including from A. pullulans, consistently reduced hepatic fat accumulation and liver enzyme levels in NAFLD animal models.
Foods DOI: 10.3390/foods12173279 PMID: 37685211
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Review 2022

Aureobasidium spp. and their applications in biotechnology

Aureobasidium species produce multiple enzymes and commercially relevant natural products.
Process Biochemistry DOI: 10.1016/j.procbio.2022.03.006
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In Vivo 2022

Hepatoprotective Effects of Aureobasidium pullulans Derived β-1,3–1,6 Glucans in a Murine Model of Non-alcoholic Steatohepatitis

A. pullulans strains AFO-202 and N-163 β-glucans significantly reduced liver steatosis, inflammation, and fibrosis scores in a murine NASH model.
Journal of Clinical and Experimental Hepatology DOI: 10.1016/j.jceh.2022.06.008 PMID: 36340302
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Clinical 2022

Improvement of sleep and melatonin in children with autism spectrum disorder after β‐1,3/1,6‐glucan consumption: An open‐label prospective pilot clinical study

AFO-202 AP-beta-glucan significantly improved behavioral scores and sleep quality in ASD children
Brain and Behavior DOI: 10.1002/brb3.2750 PMID: 35993920
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In Vivo 2022

Oral administration of botryosphaeran [(1 → 3)(1 → 6)‐β‐d‐glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception

Botryosphaeran — a fungal β-(1→3)/(1→6)-glucan — demonstrates immunostimulatory and antioxidant properties.
Cell Biochemistry and Function DOI: 10.1002/cbf.3727 PMID: 35788958
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In Vivo 2022

PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model

Beta-glucan and anti-PD-L1 were tested together in a mouse melanoma model.
Cancer Immunology, Immunotherapy DOI: 10.1007/s00262-022-03276-4
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In Vitro 2021

Affinity characteristics of anti-β-(1→3)-d-glucan monoclonal antibody 3G11 by fluorescence polarization immunoassay

Antibody 3G11 binding to a synthetic beta-1,3-glucan fragment was measured.
Russian Chemical Bulletin DOI: 10.1007/s11172-021-3175-6
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In Vitro 2021

Anti-inflammatory effects of β-1,3-1,6-glucan derived from black yeast Aureobasidium pullulans in RAW264.7 cells

Low-molecular-weight A. pullulans β-glucan (LMW-AP-FBG) significantly inhibited LPS-induced production of TNF-α, IL-6, IL-1β, and nitric oxide in RAW264.7 macrophages.
International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2021.10.065 PMID: 34678386
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Review 2021

Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review

High-purity β-1,3/1,6-glucan shows superior immunostimulatory activity versus lower-purity preparations.
Nutrients DOI: 10.3390/nu13010242
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Review 2021

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Medicinal fungi β-glucans reprogram tumor microenvironment by activating M1 macrophages and NK cells.
Journal of Fungi DOI: 10.3390/jof7040250
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In Vivo 2021

The effects of oral administration of Aureobasidium pullulans-cultured fluid containing β-glucan on concanavalin A injected mice

A. pullulans cultured fluid was tested in a mouse model of immune-mediated liver injury.
Heliyon DOI: 10.1016/j.heliyon.2021.e07277
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Patent 2021

Therapeutic agent for influenza virus infection-EU (European Patent No. 2486931)

European patent record concerning a claimed therapeutic agent for influenza virus infection.
Nutrients
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In Vivo 2021

β-glucan from Aureobasidium pullulans augments the anti-tumor immune responses through activated tumor-associated dendritic cells

A. pullulans beta-glucan was tested in mouse tumor and immune-cell models.
International Immunopharmacology DOI: 10.1016/j.intimp.2021.108265
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Review 2020

Functional activities of beta-glucans in the prevention or treatment of cervical cancer

β-glucans have multiple anti-cancer activities: immune killing, anti-proliferative effects, and TME modulation.
Journal of Ovarian Research DOI: 10.1186/s13048-020-00626-7
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In Vitro 2020

In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi

Taxifolin-rich Japanese-larch extract was tested in cultured macrophage-related and adipocyte cells.
Heliyon DOI: 10.1016/j.heliyon.2020.e05505
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In Vitro 2020

The effect of Candida cell wall beta-glucan on treatment-resistant LL/2 cancer cell line: in vitro evaluation

Candida cell wall β-glucan activates innate immunity through Dectin-1 in purified form.
Molecular Biology Reports DOI: 10.1007/s11033-020-05459-7 PMID: 32323263
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Review 2019

Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials

β-glucans have robust supplement evidence for immune support; pharmaceutical applications need stronger clinical data.
Molecules DOI: 10.3390/molecules24071251
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In Vitro 2019

Cell cytotoxity and anti-glycation activity of taxifolin-rich extract from Japanese larch, Larix kaempferi

Taxifolin-rich Japanese-larch extract was studied in THP-1 cells and glycation assays.
Heliyon DOI: 10.1016/j.heliyon.2019.e02047
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In Vivo 2019

Inhibition of tumor growth by β-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice

Three mushroom-derived beta-glucans were tested in S-180 tumor-bearing mice.
Carbohydrate Polymers DOI: 10.1016/j.carbpol.2019.03.006
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Review 2018

An introduction to immunology and immunopathology

Overview of innate and adaptive immune mechanisms.
Allergy, Asthma & Clinical Immunology DOI: 10.1186/s13223-018-0278-1
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Review 2018

Beta-Glucans as a Therapeutic Agent: Literature Review

Broad review of immune, metabolic, gastrointestinal, and cancer-related research.
Madridge Journal of Food Technology DOI: 10.18689/mjft-1000123
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Review 2018

Consumption of β-glucans to spice up T cell treatment of tumors: a review

Review proposes beta-glucans as adjuncts to T-cell cancer therapy.
Expert Opinion on Biological Therapy DOI: 10.1080/14712598.2018.1523392
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Review 2018

Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles

Review of beta-glucan strategies for changing the tumor microenvironment.
Frontiers in Immunology DOI: 10.3389/fimmu.2018.00341
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In Vitro 2018

Production of low-molecular weight soluble yeast β-glucan by an acid degradation method

45% sulfuric acid produced soluble low-molecular-weight yeast glucan.
International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2017.10.094
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In Vitro 2018

Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan

Gamma irradiation reduced the molecular weight of oat beta-glucan.
Radiation Physics and Chemistry DOI: 10.1016/j.radphyschem.2017.08.018
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Review 2018

The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System

Fungal beta-glucan responses vary with structure, purity, receptor, and immune-cell type.
Frontiers in Immunology DOI: 10.3389/fimmu.2018.00673
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In Vitro 2018

The effects of gene disruption of Kre6-like proteins on the phenotype of β-glucan-producing Aureobasidium pullulans

Two Kre6-like proteins were studied through gene disruption in A. pullulans M-2.
Applied Microbiology and Biotechnology DOI: 10.1007/s00253-018-8947-z
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Review 2018

β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties

The review discusses beta-glucans as possible vaccine and immunotherapy adjuvants.
Vaccine DOI: 10.1016/j.vaccine.2018.07.038
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In Vitro 2017

Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression

A soybean-derived preparation and A. pullulans beta-glucan were tested in cultured Mono Mac 6 cells.
Scientific Reports DOI: 10.1038/s41598-017-03053-9 PMID: 28588201
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In Vivo 2017

Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection

Injected A. pullulans cultured fluid increased IL-18-related responses in mice.
The Journal of Biochemistry DOI: 10.1093/jb/mvx062
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In Vivo 2017

The β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers

Shiitake beta-glucan inhibited an MCF-7 tumor model under study conditions.
Oncotarget DOI: 10.18632/oncotarget.21411
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In Vitro 2017

β-(1 → 3,1 → 6)-d-glucans produced by Diaporthe sp. endophytes: Purification, chemical characterization and antiproliferative activity against MCF-7 and HepG2-C3A cells

Beta-1,3/1,6-glucans from two Diaporthe strains were characterized.
International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2016.10.048
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Review 2016

A critical review on production and industrial applications of beta-glucans

The review covers production and industrial use of beta-glucans from multiple sources.
Food Hydrocolloids DOI: 10.1016/j.foodhyd.2015.07.003
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In Vivo 2016

Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism

Lentinan β-glucan demonstrated significant anti-tumor activity through macrophage and NK cell activation.
Scientific Reports DOI: 10.1038/srep28802
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In Vitro 2015

Anticancer properties of low molecular weight oat beta-glucan – An in vitro study

Low-molecular-weight oat glucan reduced viability in two cancer cell models.
International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2015.05.035
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Review 2015

Molecular Interactions of β-(1→3)-Glucans with Their Receptors

The review covers Dectin-1, CR3, glycolipids, langerin, and carbohydrate-binding modules.
Molecules DOI: 10.3390/molecules20069745
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In Vivo 2015

Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice

A. pullulans beta-glucan was studied in high-fat-diet-fed mice.
Scientific Reports DOI: 10.1038/srep10457
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In Vivo 2015

Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

Oral AP-beta-glucan was tested in high-fat-diet-fed ApoE-deficient mice.
Journal of Functional Foods DOI: 10.1016/j.jff.2015.06.044
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In Vitro 2015

Pro-apoptotic properties of (1,3)(1,4)-β-d-glucan from Avena sativa on human melanoma HTB-140 cells in vitro

Oat beta-glucan induced apoptosis-related changes in HTB-140 cells.
International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2014.09.033
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In Vitro 2015

Stimulation of Macrophages with the β-Glucan Produced by Aureobasidium pullulans Promotes the Secretion of Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL)

AP-PG increased TRAIL expression in macrophage-like cells.
PLOS ONE DOI: 10.1371/journal.pone.0124809
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In Vivo 2015

β-Glucan from Saccharomyces cerevisiae Induces IFN-γ Production In Vivo in BALB/c Mice

Baker's-yeast beta-glucan preparations were compared in mouse experiments.
In Vivo PMID: 25977381
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In Vitro 2014

Aureobasidium pullulans as a source of liamocins (heavy oils) with anticancer activity

A. pullulans (clade 11) strains from Thailand produced 7–8.6 g/L of liamocins with selective anticancer activity against lung, colon, breast, and CNS cancer cell lines.
World Journal of Microbiology and Biotechnology DOI: 10.1007/s11274-014-1639-7 PMID: 24659335
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In Vitro 2014

Stimulation with the Aureobasidium pullulans-produced β-glucan effectively induces interferon stimulated genes in macrophage-like cell lines

AP-PG induced several interferon-stimulated genes in macrophage-like cells.
Scientific Reports DOI: 10.1038/srep04777
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In Vitro 2013

Aureobasidium pullulans culture supernatant significantly stimulates R-848-activated phagocytosis of PMA-induced THP-1 macrophages

A. pullulans cultured fluid enhanced selected R-848 macrophage responses.
Immunopharmacology and Immunotoxicology DOI: 10.3109/08923973.2013.800106
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In Vitro 2013

Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent

Soluble yeast glucan bound human neutrophils and monocytes.
Frontiers in Immunology DOI: 10.3389/fimmu.2013.00230
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In Vitro 2013

Improved β-glucan Yield Using an Aureobasidium pullulans M-2 Mutant Strain in a 200-L Pilot Scale Fermentor Targeting Industrial Mass Production

The M-2 mutant increased beta-glucan production with less pigment.
Biotechnology and Bioprocess Engineering DOI: 10.1007/s12257-013-0516-9
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Review 2013

Relevance of signaling molecules for apoptosis induction on influenza A virus replication

Influenza proteins can manipulate host apoptosis pathways.
Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2013.10.100
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In Vivo 2012

A small scale study on the effects of oral administration of the β-glucan produced by Aureobasidium pullulans on milk quality and cytokine expressions of Holstein cows, and on bacterial flora in the intestines of Japanese black calves

A small study examined A. pullulans cultured fluid in cows and calves.
BMC Research Notes DOI: 10.1186/1756-0500-5-189
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In Vitro 2012

Effect of molecular size and modification pattern on the internalization of water soluble β-(1 → 3)-(1 → 4)-glucan by primary murine macrophages

A 10-kDa cereal beta-glucan was readily internalized by mouse macrophages.
The International Journal of Biochemistry & Cell Biology DOI: 10.1016/j.biocel.2012.02.018
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In Vivo 2012

Effect of Water-Soluble Fraction from Lysozyme-Treated Enterococcus faecalis FK-23 on Mortality Caused by Influenza A Virus in Mice

An E. faecalis fraction improved survival in an influenza mouse model.
Viral Immunology DOI: 10.1089/vim.2011.0056
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In Vivo 2012

Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population

Osteopontin influenced influenza severity in mice.
Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2011.11.100
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In Vitro 2012

Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages

SR-A and TLR4 cooperated in an LPS-stimulated macrophage pathway.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research DOI: 10.1016/j.bbamcr.2012.05.004
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In Vivo 2012

β-Glucan Derived from Aureobasidium pullulans Is Effective for the Prevention of Influenza in Mice

Oral A. pullulans cultured fluid improved outcomes in an influenza mouse model.
PLoS ONE DOI: 10.1371/journal.pone.0041399
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In Vitro 2011

Hepatitis C Virus NS3 Protein Can Activate the Notch-Signaling Pathway through Binding to a Transcription Factor, SRCAP

HCV NS3 altered Notch-related signaling in a cell model.
PLoS ONE DOI: 10.1371/journal.pone.0020718
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In Vitro 2011

Immunomodulatory β-Glucan from Lentinus edodes Activates Mitogen-activated Protein Kinases and Nuclear Factor-κB in Murine RAW 264.7 Macrophages

Lentinan activated selected MAPK and NF-kappa-B pathways.
Journal of Biological Chemistry DOI: 10.1074/jbc.M111.246470
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Review 2011

Stimulatory Effect of β-glucans on Immune Cells

Beta-glucan activity depends strongly on structure and formulation.
Immune Network DOI: 10.4110/in.2011.11.4.191
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In Vitro 2010

Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

DAP3 supported TCR-mediated apoptosis in thymocyte models.
Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2010.04.018
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In Vitro 2010

Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction

DELE binds DAP3 and supports death-receptor apoptosis signaling.
Apoptosis DOI: 10.1007/s10495-010-0519-3
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In Vivo 2010

Immunomodulatory effects of Aureobasidium pullulans SM-2001 exopolymers on the cyclophosphamide-treated mice

In cyclophosphamide-treated mice, oral or subcutaneous exopolymers partially reversed reductions in immune-cell and cytokine measures.
Journal of Microbiology and Biotechnology PMID: 20208453
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In Vitro 2010

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon Promoter Stimulator 1

Influenza polymerase bound IPS-1 in cell experiments.
Journal of Biological Chemistry DOI: 10.1074/jbc.M110.112458
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Review 2010

Potential of the β-glucans to enhance innate resistance to biological agents

Review links beta-glucan structure with innate immune activity.
Expert Review of Anti-Infective Therapy DOI: 10.1586/eri.10.10
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In Vitro 2010

Requirement for Siva-1 for replication of influenza A virus through apoptosis induction

Siva-1 promoted influenza-associated apoptosis in A549 cells.
Journal of General Virology DOI: 10.1099/vir.0.028316-0
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In Vitro 2009

IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

IPS-1 bound DAP3 during detachment-induced apoptosis.
Cell Death & Differentiation DOI: 10.1038/cdd.2009.97
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Review 2009

The effects of β-glucan on human immune and cancer cells

Review covers Dectin-1, CR3, TLR2/6, and multiple immune-cell types.
Journal of Hematology & Oncology DOI: 10.1186/1756-8722-2-25
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In Vivo 2009

Therapeutic potential of various β-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy

Yeast glucan outperformed tested mushroom extracts in mouse antibody therapy models.
Cancer Biology & Therapy DOI: 10.4161/cbt.8.3.7337
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Clinical 2008

A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy

Small phase I/II study enrolled 20 patients receiving chemotherapy.
Journal of Experimental & Clinical Cancer Research DOI: 10.1186/1756-9966-27-40
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In Vivo 2008

Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae

Mutant-yeast glucan reduced metastasis in several mouse models.
International Immunopharmacology DOI: 10.1016/j.intimp.2007.10.005
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In Vitro 2008

Structural characterisation and biological activities of a unique type β-d-glucan obtained from Aureobasidium pullulans

NMR identified a highly branched A. pullulans beta-glucan structure.
Glycoconjugate Journal DOI: 10.1007/s10719-008-9147-3
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Clinical 2007

Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer

Short-term study included 23 women with advanced breast cancer.
International Immunopharmacology DOI: 10.1016/j.intimp.2006.08.011
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RCT 2007

Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial

A six-week trial compared concentrated oat beta-glucan with dextrose in 75 adults.
Nutrition Journal DOI: 10.1186/1475-2891-6-6 PMID: 17386092
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In Vitro 2007

LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma

LKB1 and DAP3 cooperated in apoptosis signaling in osteosarcoma cells.
Anticancer Res PMID: 17465200
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In Vitro 2007

Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component

Beta-(1,6)-glucan strongly stimulated human neutrophils ex vivo.
Cell Host & Microbe DOI: 10.1016/j.chom.2007.06.002
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Review 2005

Immune recognition of fungal β-glucans

Multiple receptors recognize fungal beta-glucans.
Cellular Microbiology DOI: 10.1111/j.1462-5822.2005.00505.x
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In Vivo 2005

Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model

Agaricus glucan affected apoptosis pathways in ovarian-cancer cells.
Journal of Cancer Research and Clinical Oncology DOI: 10.1007/s00432-005-0672-1
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In Vivo 2003

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

A distinct accessory-cell population supported primed CD4 T cells.
Immunity DOI: 10.1016/S1074-7613(03)00110-9
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Review 2003

Fungal β-Glucans and Mammalian Immunity

Fungal beta-glucans engage mammalian innate immune recognition.
Immunity DOI: 10.1016/S1074-7613(03)00233-4
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In Vitro 2003

Hepatitis C Virus Nonstructural Protein NS3 Binds to Sm-D1, a Small Nuclear Ribonucleoprotein Associated with Autoimmune Disease

Hepatitis C virus NS3 was found to interact with the host protein Sm-D1.
Microbiology and Immunology DOI: 10.1111/j.1348-0421.2003.tb03423.x
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In Vitro 2003

Pneumocystis carinii Cell Wall β-Glucans Initiate Macrophage Inflammatory Responses through NF-κB Activation

Pneumocystis beta-glucan activated macrophage NF-kappa-B.
Journal of Biological Chemistry DOI: 10.1074/jbc.M301426200
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In Vitro 2001

Immune recognition. A new receptor for beta-glucans

Dectin-1 was identified as a beta-glucan receptor.
Nature Immunology DOI: 10.3410/f.1000359.9911
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In Vitro 1999

Identification of a new element for RNA replication within the internal ribosome entry site of poliovirus RNA.

Poliovirus stem-loop II contributed to RNA replication and translation.
Journal of General Virology DOI: 10.1099/0022-1317-80-4-917
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In Vitro 1999

Lower concentration of La protein required for internal ribosome entry on hepatitis C virus RNA than on poliovirus RNA

Lower La protein concentration is sufficient for HCV IRES-mediated translation versus poliovirus.
Journal of General Virology DOI: 10.1099/0022-1317-80-9-2319 PMID: 10501483
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In Vitro 1994

Molecular cloning and expression of an isomalto-dextranase gene from Arthrobacter globiformis T6

An isomalto-dextranase gene from Arthrobacter globiformis was cloned and expressed.
Journal of Bacteriology DOI: 10.1128/jb.176.24.7730-7734.1994
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