An Aureobasidium pullulans M-2 mutant was developed for higher beta-glucan production with less dark pigment. In optimized 3-liter fermentation, beta-glucan reached 9.9 g/L with a reported yield of 0.52 g per g consumed sucrose, and similar productivity was reproduced at 200-liter scale. GC/MS and NMR supported beta-(1,3)(1,6) linkages. This is a fermentation and manufacturing study, not evidence that the resulting material provides a health benefit or is clinically safe.
An A. pullulans mutant and optimized fermentation process were tested at pilot scale.
Beta-glucan reached about 9.9 g/L and the yield was reproduced in a 200-liter fermentor.
Manufacturing performance does not establish clinical safety or efficacy.
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Moriya, Naoyuki; Moriya, Yukiko; Nomura, Hideo; Kusano, Kisato; Asada, Yukoh; Uchiyama, Hirofumi; Park, Enoch Y.; Okabe, Mitsuyasu. Improved β-glucan Yield Using an Aureobasidium pullulans M-2 Mutant Strain in a 200-L Pilot Scale Fermentor Targeting Industrial Mass Production. Biotechnology and Bioprocess Engineering. 2013. DOI: 10.1007/s12257-013-0516-9.
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