Researchers orally administered Aureobasidium pullulans cultured fluid enriched in beta-(1,3)(1,6)-glucan to mice infected with influenza A/PR8. Treated groups showed higher survival after the reported infection challenge and lower lung virus titers. In RAW264.7 cells, purified AP beta-glucan increased RIG-I and MDA5 expression and pretreatment reduced viral replication. The intervention was a cultured fluid in mice, and the supporting mechanism came from cell assays; this does not establish influenza prevention or treatment in humans.
Oral A. pullulans cultured fluid was tested in an influenza A mouse model, with supporting macrophage-cell assays.
The study reported improved mouse survival, lower lung virus titers, and increased antiviral-sensor expression in cells.
Mouse and cell results do not establish prevention or treatment efficacy in humans.
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Muramatsu D., Iwai A., Aoki S., Uchiyama H., Nakagawa T., Kawata K., Okabe M., Hara M., Ohno N., Inagaki N.. β-Glucan Derived from Aureobasidium pullulans Is Effective for the Prevention of Influenza in Mice. PLoS ONE. 2012. DOI: 10.1371/journal.pone.0041399.
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