In an influenza A mouse model, intraperitoneal administration of Aureobasidium pullulans cultured fluid increased serum IL-18 and splenic IFN-gamma-producing CD4-positive cells. Cell experiments also showed IL-18 production in a dendritic-cell line and peritoneal cells. Compared with alum, the cultured fluid caused less recruitment of neutrophils and inflammatory macrophages in the tested setting. The material was a cultured fluid containing beta-glucan, the route was injection, and the results do not establish prevention or treatment effects from oral use in humans.
Aureobasidium pullulans cultured fluid was examined as an immune adjuvant during influenza A infection in mice and in cell assays.
Injected cultured fluid increased IL-18 and IFN-gamma-producing CD4-positive cells and produced less local inflammatory-cell recruitment than alum.
The study used injected cultured fluid in mice. It does not establish oral prevention or treatment effects in humans.
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Fujikura, Daisuke; Muramatsu, Daisuke; Toyomane, Kochi; Chiba, Satoko; Daito, Takuji; Iwai, Atsushi; Kouwaki, Takahisa; Okamoto, Masaaki; Higashi, Hideaki; Kida, Hiroshi; Oshiumi, Hiroyuki. Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection. The Journal of Biochemistry. 2017. DOI: 10.1093/jb/mvx062.
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