Effect of Water-Soluble Fraction from Lysozyme-Treated Enterococcus faecalis FK-23 on Mortality Caused by Influenza A Virus in Mice

Kondoh, Masatoshi; Fukada, Kazutake; Fujikura, Daisuke; Shimada, Takashi; Suzuki, Yoshimitsu; Iwai, Atsushi; Miyazaki, Tadaaki · Viral Immunology · DOI: 10.1089/vim.2011.0056

Research Archive

TL;DR — Key Findings

An E. faecalis fraction improved survival in an influenza mouse model.
Lung IL-10 expression increased after infection.
No beta-glucan or human intervention was tested.

Abstract

Mice received an oral water-soluble fraction from lysozyme-treated Enterococcus faecalis FK-23 before and after a lethal influenza A challenge. The treated group had higher survival and increased lung IL-10 messenger RNA after infection. The experiment concerns a heat-treated bacterial preparation, not beta-glucan or Aureobasidium pullulans, and mouse survival results do not establish influenza prevention or treatment in humans.

Summary

Study

An oral E. faecalis FK-23 fraction was tested in influenza-infected mice.

Finding

Survival and lung IL-10 expression increased in the treated group.

Limit

This is a mouse study of a bacterial preparation, not beta-glucan.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Kondoh, Masatoshi; Fukada, Kazutake; Fujikura, Daisuke; Shimada, Takashi; Suzuki, Yoshimitsu; Iwai, Atsushi; Miyazaki, Tadaaki. Effect of Water-Soluble Fraction from Lysozyme-Treated Enterococcus faecalis FK-23 on Mortality Caused by Influenza A Virus in Mice. Viral Immunology. 2012. DOI: 10.1089/vim.2011.0056.

Study Details

Study Type

In Vivo

Published

2012

Journal

Viral Immunology

Authors

Kondoh, Masatoshi; Fukada, Kazutake; Fujikura, Daisuke; Shimada, Takashi; Suzuki, Yoshimitsu; Iwai, Atsushi; Miyazaki, Tadaaki

DOI

10.1089/vim.2011.0056

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