LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma

This cell study examined signaling involved in TRAIL-induced apoptosis in osteosarcoma. The researchers found that the kinase LKB1 associated with DAP3, a protein involved in activation of procaspase-8. Expression of either protein promoted apoptosis in osteosarcoma cells, while co-expression produced a stronger response; a kinase-dead LKB1 mutant reduced DAP3-related apoptosis. These experiments identify a possible role for LKB1 and DAP3 in tumor-cell death signaling. They do not test beta-glucan, a treatment in animals or patients, or the clinical value of LKB1 as a biomarker.