This cell-based virology study examined how influenza A virus suppresses type I interferon signaling. Viral polymerase subunits bound IPS-1 and inhibited RIG-I/IPS-1-driven IFN-beta promoter activity independently of NS1, with PB2-containing combinations showing strong inhibition. PB2 also reduced infection-induced endogenous IFN-beta transcription. The study describes a viral immune-evasion mechanism and did not test beta-glucan or Aureobasidium pullulans.
Influenza polymerase subunits were tested for effects on IPS-1-dependent interferon signaling.
The subunits bound IPS-1 and inhibited IFN-beta promoter activity, with a prominent role for PB2.
This mechanistic study contains no beta-glucan intervention.
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Iwai, Atsushi; Shiozaki, Takuya; Kawai, Taro; Akira, Shizuo; Kawaoka, Yoshihiro; Takada, Ayato; Kida, Hiroshi; Miyazaki, Tadaaki. Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon Promoter Stimulator 1. Journal of Biological Chemistry. 2010. DOI: 10.1074/jbc.M110.112458.
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