This cell-based study found that hepatitis C virus NS3 protein bound the transcriptional regulators SRCAP and p400 and increased Notch-responsive Hes-1 promoter activity in Hep3B cells. Reducing SRCAP and p400 expression weakened that response, suggesting a possible pathway connecting persistent HCV infection with altered host-cell signaling. The paper did not investigate beta-glucan or Aureobasidium pullulans; its relevance to this archive is indirect background on viral pathogenesis.
The interaction of hepatitis C virus NS3 protein with SRCAP, p400, and Notch-related transcription in liver-derived cells.
NS3 bound SRCAP and p400 and increased Hes-1 promoter activity; combined silencing reduced the response.
This is cell-based viral-pathogenesis research. It did not study beta-glucan or Aureobasidium pullulans.
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Iwai A., Takegami T., Shiozaki T., Miyazaki T.. Hepatitis C Virus NS3 Protein Can Activate the Notch-Signaling Pathway through Binding to a Transcription Factor, SRCAP. PLoS ONE. 2011. DOI: 10.1371/journal.pone.0020718.
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