This laboratory study compared beta-1,3/1,6-glucans isolated from extracellular material, cell walls, and intracellular material of Aureobasidium pullulans CGMCC19650. The three preparations differed in molecular-weight distribution and physical structure. In culture-based tests they inhibited Escherichia coli and Staphylococcus aureus, but not Candida albicans, and showed free-radical-scavenging activity. They also reduced markers of hydrogen-peroxide-induced oxidative stress in RAW264.7 macrophage cells. These findings describe in-vitro antibacterial and antioxidant activity; they do not establish clinical benefit, effective dosing, or safety in people.
Three beta-glucan fractions from A. pullulans were structurally characterized and tested against microorganisms and an oxidative-stress cell model.
Activity was observed in laboratory assays, including bacterial growth and RAW264.7-cell experiments. Human effectiveness and safety were not tested.
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Ao, Junqiu; Liu, Yuqing; Wei, Yanyu; Wang, Dahui; Wang, Chonglong; Wei, Lin; Wei, Gongyuan. Antibacterial and antioxidant activities of β-glucans derived from Aureobasidium pullulans. Food Bioscience. 2025. DOI: 10.1016/j.fbio.2025.107074.
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