This review explains how fungal beta-glucans are recognized by mammalian innate immunity and summarizes receptor and signaling research relevant to antifungal, anti-infective, and tumor-related hypotheses. It reflects an early stage of mechanistic understanding and discusses a heterogeneous literature. The review does not itself demonstrate clinical efficacy, and findings about fungal beta-glucans cannot automatically be generalized to a specific product or route of administration.
Review of fungal beta-glucan recognition and mammalian innate-immune mechanisms.
Mechanistic context does not establish clinical efficacy or interchangeability of products.
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Brown G., Gordon S.. Fungal β-Glucans and Mammalian Immunity. Immunity. 2003. DOI: 10.1016/S1074-7613(03)00233-4.
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