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In Vitro 2013

Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent

Bose, Nandita; Chan, Anissa S. H.; Guerrero, Faimola; Maristany, Carolyn M.; Qiu, Xiaohong; Walsh, Richard M.; Ertelt, Kathleen E.; Jonas, Adria Bykowski; Gorden, Keith B.; Dudney, Christine M.; Wurst, Lindsay R.; Danielson, Michael E.; Elmasry, Natalie; Magee, Andrew S.; Patchen, Myra L.; Vasilakos, John P. · Frontiers in Immunology · DOI: 10.3389/fimmu.2013.00230
Read Original Paper DOI: 10.3389/fimmu.2013.00230
Research Archive
TL;DR — Key Findings
  • Soluble yeast glucan bound human neutrophils and monocytes.
  • Complement and CR3 were central to binding.
  • The assay does not demonstrate a health outcome.

Abstract

A pharmaceutical-grade soluble yeast beta-(1,3)(1,6)-glucan was tested with human neutrophils and monocytes. Binding increased with concentration and depended on serum, time, temperature, complement component C3, and the CD11b/CD18 chains of complement receptor 3. Detection of iC3b supported complement-mediated opsonization. This ex-vivo receptor-binding study does not establish a clinical immune benefit and does not directly test Aureobasidium glucan.

Summary

Summary

Study

Soluble yeast glucan binding to human neutrophils and monocytes was characterized.

Finding

Binding depended on complement and CR3, with iC3b detected on glucan-bound cells.

Limit

Receptor binding ex vivo does not establish clinical benefit.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Bose, Nandita; Chan, Anissa S. H.; Guerrero, Faimola; Maristany, Carolyn M.; Qiu, Xiaohong; Walsh, Richard M.; Ertelt, Kathleen E.; Jonas, Adria Bykowski; Gorden, Keith B.; Dudney, Christine M.; Wurst, Lindsay R.; Danielson, Michael E.; Elmasry, Natalie; Magee, Andrew S.; Patchen, Myra L.; Vasilakos, John P.. Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent. Frontiers in Immunology. 2013. DOI: 10.3389/fimmu.2013.00230.

Study Details
Study Type
In Vitro
Published
2013
Journal
Frontiers in Immunology
Authors
Bose, Nandita; Chan, Anissa S. H.; Guerrero, Faimola; Maristany, Carolyn M.; Qiu, Xiaohong; Walsh, Richard M.; Ertelt, Kathleen E.; Jonas, Adria Bykowski; Gorden, Keith B.; Dudney, Christine M.; Wurst, Lindsay R.; Danielson, Michael E.; Elmasry, Natalie; Magee, Andrew S.; Patchen, Myra L.; Vasilakos, John P.
DOI
10.3389/fimmu.2013.00230
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