Macrophage experiments examined cooperation between scavenger receptor A (SR-A/CD204) and TLR4 during lipopolysaccharide signaling. Fucoidan enhanced LPS-related I-kappa-B-alpha phosphorylation, NF-kappa-B activity, and cytokine production in wild-type cells, but not in macrophages lacking SR-A or TLR4. The work supports receptor cooperation in this experimental inflammatory pathway. It did not test beta-glucan or Aureobasidium pullulans, and the cell findings are not evidence of a human health benefit.
Macrophage models were used to examine cooperation between SR-A and TLR4 during LPS stimulation.
Fucoidan enhanced selected NF-kappa-B and cytokine responses only when both receptors were present.
No beta-glucan or Aureobasidium intervention was tested.
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Yu, Honghui; Ha, Tuanzhu; Liu, Li; Wang, Xiaohui; Gao, Ming; Kelley, Jim; Kao, Race; Williams, David; Li, Chuanfu. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012. DOI: 10.1016/j.bbamcr.2012.05.004.
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