The study evaluated a beta-glucan from the shiitake mushroom Lentinus edodes in estrogen-receptor-positive MCF-7 breast-cancer models. Tumor growth in nude mice was reduced by about 53% under the reported conditions, and tissue and cell experiments showed changes in proliferation, apoptosis markers, and several signaling pathways. This is preclinical research using a mushroom-derived glucan; it does not demonstrate effectiveness or safety in patients and cannot be assumed to apply to Aureobasidium beta-glucan.
Shiitake-derived beta-glucan was tested in MCF-7 breast-cancer cell and nude-mouse tumor models.
The study reported about 53% tumor-growth inhibition and changes in proliferation, apoptosis, and signaling markers.
This is preclinical research on a mushroom glucan. It does not demonstrate patient benefit or equivalence with Aureobasidium glucan.
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Xu, Hui; Zou, Siwei; Xu, Xiaojuan. The β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers. Oncotarget. 2017. DOI: 10.18632/oncotarget.21411.
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