Requirement for Siva-1 for replication of influenza A virus through apoptosis induction

Shiozaki, T.; Iwai, A.; Kawaoka, Y.; Takada, A.; Kida, H.; Miyazaki, T. · Journal of General Virology · DOI: 10.1099/vir.0.028316-0

Research Archive

TL;DR — Key Findings

Siva-1 promoted influenza-associated apoptosis in A549 cells.
Knockdown also reduced viral replication through a caspase-related mechanism.
No beta-glucan or Aureobasidium intervention was studied.

Abstract

This cell study investigated the host protein Siva-1 during influenza A infection of human A549 lung-derived cells. Increasing Siva-1 made infected cells more susceptible to apoptosis, whereas Siva-1 knockdown reduced apoptosis and suppressed viral replication; a caspase inhibitor removed the replication effect. The results link caspase-dependent apoptosis with influenza replication in this model. No beta-glucan or Aureobasidium intervention was tested.

Summary

Study

Siva-1 was manipulated in influenza-infected A549 cells.

Finding

Siva-1 supported caspase-dependent apoptosis and viral replication in the cell model.

Limit

This is mechanistic virology and contains no beta-glucan experiment.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Shiozaki, T.; Iwai, A.; Kawaoka, Y.; Takada, A.; Kida, H.; Miyazaki, T.. Requirement for Siva-1 for replication of influenza A virus through apoptosis induction. Journal of General Virology. 2010. DOI: 10.1099/vir.0.028316-0.

Study Details

Study Type

In Vitro

Published

2010

Journal

Journal of General Virology

Authors

Shiozaki, T.; Iwai, A.; Kawaoka, Y.; Takada, A.; Kida, H.; Miyazaki, T.

DOI

10.1099/vir.0.028316-0

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