Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression

This cell-culture study examined Aureobasidium pullulans cultured fluid produced with Kurosengoku soybean and containing beta-glucan. In Mono Mac 6 cells, the preparation increased expression of thrombospondin-1. Combining beta-glucan with Kurosengoku soybean extract produced a larger expression response than soybean extract alone, which the authors interpreted as a synergistic effect. The experiment measured gene or protein expression in a cultured human monocyte-derived cell line. It did not test tumor growth, blood-vessel formation, cancer treatment, or outcomes in animals or people.