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In Vitro 2007

Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component

Rubin-Bejerano I., Abeijon C., Magnelli P., Grisafi P., Fink G. · Cell Host & Microbe · DOI: 10.1016/j.chom.2007.06.002
Read Original Paper DOI: 10.1016/j.chom.2007.06.002
Research Archive
TL;DR — Key Findings
  • Beta-(1,6)-glucan strongly stimulated human neutrophils ex vivo.
  • Complement deposition and fungal engulfment were involved.
  • The study does not show an oral product health outcome.

Abstract

Human neutrophils were exposed to different fungal cell-wall beta-glucans and glucan-coated beads. Beta-(1,6)-glucan stimulated engulfment, reactive-oxygen production, heat-shock responses, and complement deposition more strongly than the tested beta-(1,3)-glucan, and contributed to uptake of Candida albicans. These ex-vivo findings concern isolated fungal wall components and neutrophil mechanisms; they do not establish safety or therapeutic benefit from an oral beta-glucan product.

Summary

Summary

Study

Human neutrophil responses to beta-(1,6)- and beta-(1,3)-glucans were compared.

Finding

Beta-(1,6)-glucan more strongly supported phagocytosis and complement-related responses.

Limit

Ex-vivo neutrophil assays do not establish clinical benefit.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Rubin-Bejerano I., Abeijon C., Magnelli P., Grisafi P., Fink G.. Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component. Cell Host & Microbe. 2007. DOI: 10.1016/j.chom.2007.06.002.

Study Details
Study Type
In Vitro
Published
2007
Journal
Cell Host & Microbe
Authors
Rubin-Bejerano I., Abeijon C., Magnelli P., Grisafi P., Fink G.
DOI
10.1016/j.chom.2007.06.002
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