This study compared Saccharomyces cerevisiae beta-glucan preparations of different molecular sizes in BALB/c mouse experiments. Oral administration increased interferon-gamma measurements in the in-vivo model, with a water-soluble preparation showing a stronger response than a particulate preparation. The same response was not observed when mouse leukocytes were exposed in vitro. The work concerns baker's-yeast beta-glucan, not Aureobasidium-derived beta-glucan, and measures an immune biomarker rather than resistance to infection, tumor control, or a clinical health outcome.
Different baker's-yeast beta-glucan preparations were tested in BALB/c mice and isolated mouse leukocytes.
Interferon-gamma increased in vivo but not in the cell experiment. The study did not test human outcomes or AP-glucan.
Javmen, Artur; Nemeikaite-Ceniene, Ausra; Bratchikov, Maksim; Grigiskis, Saulius; Grigas, Fortunatas; Jonauskiene, Irena; Zabulyte, Danguole; Mauricas, Mykolas. β-Glucan from Saccharomyces cerevisiae Induces IFN-γ Production In Vivo in BALB/c Mice. In Vivo. 2015. PMID: 25977381.
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