Compositions promoting cytokine production in macrophages – Japan (Patent No. 5559173)
Patent Details
Country of RegistrationJapan
Patent No.No. 5559173Registration DateJune 13, 2014
The combination of Aureo culture medium and leciquimod, a compound with antiviral activity, has been proven to synergistically activate macrophages, and a new immunostimulatory effect of Aureo culture medium has been recognized.When activated, macrophages, a type of immune cell, processed cancer cells and cells damaged or killed by anticancer drugs through phagocytosis, and further activated them to produce physiologically active substances called cytokines, thereby enhancing immunity.※ Reciquimod has antiviral and antitumor activity.
This Japanese patent covers compositions using Aureobasidium pullulans-derived β-glucan for promoting cytokine production in macrophages, protecting the specific immunostimulatory formulation approach.
The patent claims specific methods and compositions for maximizing AP β-glucan's ability to stimulate macrophage cytokine production, including TNF-α, IL-6, and IL-12. These cytokine profiles drive innate immune activation relevant to anti-tumor and anti-pathogen defense.
Patents protecting cytokine-promoting applications of AP-glucan reflect the commercial value of its macrophage activation properties. This intellectual property protection encourages continued investment in AP-glucan-based immune health products.
Uchiyama H., Iwai A., Nagahara Y.. Compositions promoting cytokine production in macrophages – Japan (Patent No. 5559173). Japanese Patent Office. 2023.
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