CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

Kim M., Gaspal F., Wiggett H., McConnell F., Gulbranson-Judge A., Walber C., Lane P. · Immunity · DOI: 10.1016/S1074-7613(03)00110-9

Research Archive

TL;DR — Key Findings

A distinct accessory-cell population supported primed CD4 T cells.
OX40 and CD30 pathways contributed to the effect.
This is indirect immunology, not beta-glucan evidence.

Abstract

This study identified CD4-positive, CD3-negative accessory cells at sites where T cells help B cells. Unlike conventional dendritic cells, these cells expressed high levels of OX40 ligand and CD30 ligand and supported survival of primed Th2 cells and memory T-cell help for B cells in experimental systems. The work describes immune-cell costimulation and memory biology. It did not investigate beta-glucan or Aureobasidium pullulans.

Summary

Study

CD4-positive, CD3-negative accessory cells were examined in T- and B-cell collaboration.

Finding

OX40 and CD30 ligand signaling supported primed T-cell survival and memory help.

Limit

No beta-glucan intervention was tested.

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Citation

Kim M., Gaspal F., Wiggett H., McConnell F., Gulbranson-Judge A., Walber C., Lane P.. CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells. Immunity. 2003. DOI: 10.1016/S1074-7613(03)00110-9.

Study Details

Study Type

In Vivo

Published

2003

Journal

Immunity

Authors

Kim M., Gaspal F., Wiggett H., McConnell F., Gulbranson-Judge A., Walber C., Lane P.

DOI

10.1016/S1074-7613(03)00110-9

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