This review examines beta-glucans and beta-glucan-based nanoparticles as possible tools for modifying the immunosuppressive tumor microenvironment. It discusses recognition by innate immune receptors, effects on antigen-presenting cells and myeloid cells, and delivery strategies intended to support anti-tumor immune responses. The article brings together mechanistic and mainly preclinical evidence; it does not establish clinical efficacy in people or specifically test Aureobasidium pullulans beta-glucan.
A review of beta-glucans and beta-glucan nanoparticles as immune modulators of the tumor microenvironment.
Receptor-mediated effects on myeloid and antigen-presenting cells may help make some tumors more responsive to immune attack.
The evidence is mainly mechanistic and preclinical. This is not a human efficacy trial and not a direct test of Aureobasidium pullulans beta-glucan.
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Zhang, Mei; Kim, Julian A.; Huang, Alex Yee-Chen. Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles. Frontiers in Immunology. 2018. DOI: 10.3389/fimmu.2018.00341.
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