Oat beta-(1,3)(1,4)-glucan was applied to human HTB-140 melanoma cells in vitro. The study reported concentration-dependent cytotoxicity, caspase-3/7 activation, annexin V binding, reduced ATP and mitochondrial potential, and cell-cycle changes consistent with apoptosis; the reported 24-hour LD50 was about 195 micrograms per milliliter. This single-cell-line experiment is preliminary, does not show an effect in patients, and concerns oat glucan rather than Aureobasidium beta-(1,3)(1,6)-glucan.
Oat beta-glucan was applied to HTB-140 melanoma cells.
Multiple measurements indicated concentration-dependent cytotoxicity and mitochondrial apoptosis in vitro.
A single oat-glucan cell model cannot establish human benefit or equivalence with Aureobasidium glucan.
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Parzonko A., Makarewicz-Wujec M., Jaszewska E., Harasym J., Kozlowska-Wojciechowska M.. Pro-apoptotic properties of (1,3)(1,4)-β-d-glucan from Avena sativa on human melanoma HTB-140 cells in vitro. International Journal of Biological Macromolecules. 2015. DOI: 10.1016/j.ijbiomac.2014.09.033.
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