Structural characterisation and biological activities of a unique type β-d-glucan obtained from Aureobasidium pullulans

NMR spectroscopy was used to characterize an Aureobasidium pullulans beta-D-glucan preparation. The major structure had a beta-(1,3) backbone with beta-(1,6) single-glucose branches about every two backbone residues, with a less abundant form branched about every three residues. The study also reported immune-cell accumulation and priming against an enteric bacterium in experimental models. Structural and preclinical findings do not establish a health benefit, dose, or safety in humans.