The effects of oral administration of Aureobasidium pullulans-cultured fluid containing β-glucan on concanavalin A injected mice

This mouse study examined oral Aureobasidium pullulans cultured fluid containing beta-glucan in a concanavalin-A model of immune-mediated liver injury. Mice receiving the cultured fluid had a smaller rise in serum alanine aminotransferase after concanavalin-A injection. Experiments using Foxp3 reporter mice also found changes in regulatory T-cell populations in blood, liver, and spleen. The authors proposed that reduced baseline inflammation could contribute to the observed enzyme change. The model does not reproduce all features of human liver disease, and the results do not establish prevention or treatment effects in people.