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In Vivo 2008

Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae

Yoon T., Kim T., Lee H., Shin K., Yun Y., Won C., Song S., Kim S. · International Immunopharmacology · DOI: 10.1016/j.intimp.2007.10.005
Research Archive
TL;DR — Key Findings
  • Mutant-yeast glucan reduced metastasis in several mouse models.
  • Results suggested an immune-mediated rather than direct cytotoxic effect.
  • Preclinical findings do not establish human cancer efficacy.

Abstract

A beta-glucan purified from a mutant Saccharomyces cerevisiae strain was tested in several mouse tumor and metastasis models. Preventive or therapeutic administration reduced reported tumor burden or metastasis and sometimes prolonged survival, while the glucan did not directly inhibit colon cancer cells in vitro. Splenocyte proliferation, macrophage cytokines, and tumoricidal activity increased, supporting an immune-mediated explanation. These are preclinical yeast-glucan results and do not demonstrate cancer treatment efficacy in patients or equivalence with Aureobasidium glucan.

Summary

Summary

Study

Mutant-yeast beta-glucan was tested in multiple mouse tumor models and immune assays.

Finding

Metastasis and tumor growth decreased in some models alongside immune-cell activation.

Limit

Mouse yeast-glucan findings do not prove patient benefit or Aureobasidium equivalence.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Yoon T., Kim T., Lee H., Shin K., Yun Y., Won C., Song S., Kim S.. Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae. International Immunopharmacology. 2008. DOI: 10.1016/j.intimp.2007.10.005.

Study Details
Study Type
In Vivo
Published
2008
Journal
International Immunopharmacology
Authors
Yoon T., Kim T., Lee H., Shin K., Yun Y., Won C., Song S., Kim S.
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