Beta-(1,6)-D-glucan extracted from Agaricus blazei mushroom was tested in ovarian-cancer cells and mouse metastasis models. The study reported p38 MAPK-related apoptosis in HRA cells and reductions in some lung and peritoneal metastasis measures after oral supplementation, although supplementation begun after intravenous tumor-cell inoculation did not reduce lung colony numbers in one assay. These mixed preclinical results concern a mushroom glucan and do not demonstrate cancer treatment efficacy or safety in patients.
Agaricus mushroom glucan was tested in cancer cells and mouse metastasis models.
Apoptosis-related effects and reductions in some metastasis measures were reported, but one lung-colony assay was negative.
Mixed preclinical findings do not establish patient benefit.
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Kobayashi H., Yoshida R., Kanada Y., Fukuda Y., Yagyu T.. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. Journal of Cancer Research and Clinical Oncology. 2005. DOI: 10.1007/s00432-005-0672-1.
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