This cell study tested Aureobasidium pullulans-produced beta-(1,3)(1,6)-glucan (AP-PG) in mouse and human macrophage-like cell lines. AP-PG increased TRAIL messenger RNA, while TNF-alpha and FasL changed less. Medium from stimulated Mono Mac 6 cells activated caspases in HeLa cells, and a TRAIL-neutralizing antibody reduced that effect. These findings identify a possible macrophage-mediated mechanism in vitro; they do not demonstrate tumor treatment efficacy or safety in people.
AP-PG was tested in macrophage-like cell lines for induction of the apoptosis-related cytokine TRAIL.
TRAIL expression increased, and conditioned medium activated caspases in HeLa cells through a TRAIL-dependent component.
This cell experiment does not establish cancer treatment effects in humans.
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Kawata K., Iwai A., Muramatsu D., Aoki S., Uchiyama H., Bhagat L., Takegami T., Inagaki N., Patel J., Bhagat H.. Stimulation of Macrophages with the β-Glucan Produced by Aureobasidium pullulans Promotes the Secretion of Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL). PLOS ONE. 2015. DOI: 10.1371/journal.pone.0124809.
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