This laboratory study examined a taxifolin-rich methanol extract of Japanese larch and related flavonoids in THP-1 cells and cell-free glycation assays. Taxifolin showed relatively low growth inhibition and cytokine induction in the tested cell line and inhibited glycation in vitro. The activity of the whole extract suggested that compounds in addition to taxifolin could contribute. The study does not involve beta-glucan or a combination with Aureobasidium beta-glucan, and it provides no evidence of synergistic supplementation or therapeutic benefit in humans.
Japanese-larch extract and flavonoids were assessed in THP-1 cells and laboratory glycation assays.
The study concerns taxifolin-rich plant extract and did not test beta-glucan, a combination product, or people.
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Muramatsu D., Uchiyama H., Kida H., Iwai A.. Cell cytotoxity and anti-glycation activity of taxifolin-rich extract from Japanese larch, Larix kaempferi. Heliyon. 2019. DOI: 10.1016/j.heliyon.2019.e02047.
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