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In Vitro 2010

Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction

Tosa N., Iwai A., Tanaka T., Kumagai Y., Onizuka S., Kanda T., Kikukawa T. · Biochemical and Biophysical Research Communications · DOI: 10.1016/j.bbrc.2010.04.018
Read Original Paper DOI: 10.1016/j.bbrc.2010.04.018
Research Archive
TL;DR — Key Findings
  • DAP3 supported TCR-mediated apoptosis in thymocyte models.
  • Its nuclear movement depended on Nur77.
  • No beta-glucan or Aureobasidium intervention was studied.

Abstract

This mechanistic study tested death-associated protein 3 (DAP3) in T-cell-receptor-mediated apoptosis. Increased DAP3 accelerated negative selection in a reaggregate thymus culture model and apoptosis in DO11.10 cells. DAP3 also moved into the nucleus during TCR-triggered apoptosis in a Nur77-dependent manner. The findings concern thymocyte selection and cell-death signaling; no beta-glucan or Aureobasidium intervention was examined.

Summary

Summary

Study

DAP3 was examined in T-cell-receptor-mediated apoptosis and thymocyte negative selection.

Finding

DAP3 accelerated apoptosis and acted downstream of Nur77 in the tested models.

Limit

This mechanistic paper contains no beta-glucan experiment.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Tosa N., Iwai A., Tanaka T., Kumagai Y., Onizuka S., Kanda T., Kikukawa T.. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Biochemical and Biophysical Research Communications. 2010. DOI: 10.1016/j.bbrc.2010.04.018.

Study Details
Study Type
In Vitro
Published
2010
Journal
Biochemical and Biophysical Research Communications
Authors
Tosa N., Iwai A., Tanaka T., Kumagai Y., Onizuka S., Kanda T., Kikukawa T.
DOI
10.1016/j.bbrc.2010.04.018
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