This laboratory study used 45% sulfuric acid at 20 °C to convert insoluble yeast beta-glucan into lower-molecular-weight soluble fractions. The lower-molecular-weight fraction contained little mannan, bound the beta-glucan receptor Dectin-1, and reduced reactive-oxygen and cytokine responses in macrophage assays under the tested conditions. The work describes a production method and in-vitro receptor activity, not safety, absorption, or clinical effectiveness in humans.
An acid-degradation method for producing soluble, low-molecular-weight yeast beta-glucan.
The low-molecular-weight fraction had little mannan, bound Dectin-1, and antagonized selected macrophage responses in vitro.
This is a processing and cell-assay study, not evidence of safety, absorption, or clinical effectiveness.
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Ishimoto Y., Ishibashi K., Yamanaka D., Adachi Y., Ohno N.. Production of low-molecular weight soluble yeast β-glucan by an acid degradation method. International Journal of Biological Macromolecules. 2018. DOI: 10.1016/j.ijbiomac.2017.10.094.
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