This laboratory study used gamma irradiation to reduce the molecular weight of oat beta-glucan and examined resulting structural and biological changes. Irradiated preparations showed stronger activity in free-radical-scavenging and enzyme-inhibition assays and greater cytotoxicity in several cancer-cell lines, while the tested normal-cell lines did not show the same response. The material was cereal-derived oat beta-glucan, not beta-1,3/1,6 Aureobasidium glucan. The assays do not demonstrate anticancer, antioxidant, or glucose-lowering benefits in people.
Oat beta-glucan was irradiated to reduce molecular weight and tested in cell-free and cultured-cell assays.
The laboratory findings concern oat beta-glucan and do not demonstrate clinical effects or AP-glucan activity.
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Hussain P., Rather S., Suradkar P., Wani S.. Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan. Radiation Physics and Chemistry. 2018. DOI: 10.1016/j.radphyschem.2017.08.018.
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