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In Vivo 2012

Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population

Sato, Kayoko; Iwai, Atsushi; Nakayama, Yosuke; Morimoto, Junko; Takada, Ayato; Maruyama, Mitsuo; Kida, Hiroshi; Uede, Toshimitsu; Miyazaki, Tadaaki · Biochemical and Biophysical Research Communications · DOI: 10.1016/j.bbrc.2011.11.100
Read Original Paper DOI: 10.1016/j.bbrc.2011.11.100
Research Archive
TL;DR — Key Findings
  • Osteopontin influenced influenza severity in mice.
  • NK-cell numbers changed with osteopontin expression.
  • No beta-glucan or Aureobasidium intervention was studied.

Abstract

This mouse study examined osteopontin during lethal influenza A infection. Osteopontin-deficient mice had more severe disease and lower survival, whereas transgenic mice had higher survival; natural-killer-cell numbers also tracked with osteopontin expression. The findings suggest a host-defense role for osteopontin through regulation of NK-cell populations. No beta-glucan or Aureobasidium intervention was tested.

Summary

Summary

Study

Osteopontin-deficient and transgenic mice were compared after influenza infection.

Finding

Osteopontin expression was associated with survival and NK-cell population changes.

Limit

This is indirect influenza immunology with no beta-glucan treatment.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Sato, Kayoko; Iwai, Atsushi; Nakayama, Yosuke; Morimoto, Junko; Takada, Ayato; Maruyama, Mitsuo; Kida, Hiroshi; Uede, Toshimitsu; Miyazaki, Tadaaki. Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population. Biochemical and Biophysical Research Communications. 2012. DOI: 10.1016/j.bbrc.2011.11.100.

Study Details
Study Type
In Vivo
Published
2012
Journal
Biochemical and Biophysical Research Communications
Authors
Sato, Kayoko; Iwai, Atsushi; Nakayama, Yosuke; Morimoto, Junko; Takada, Ayato; Maruyama, Mitsuo; Kida, Hiroshi; Uede, Toshimitsu; Miyazaki, Tadaaki
DOI
10.1016/j.bbrc.2011.11.100
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