This preclinical study extracted three beta-1,3/1,6-glucans from Lentinus edodes and tested them in mice bearing S-180 tumors using oral, intraperitoneal, and intratumoral administration. The preparations reduced tumor growth in the model and were associated with changes in CD4-positive T-cell and neutrophil populations in lymphoid organs and tumors. The work concerns mushroom-derived glucans and an animal tumor model. It does not establish cancer-treatment efficacy, dosing, or safety in humans and should not be generalized to Aureobasidium beta-glucan.
Three Lentinus edodes beta-glucans were tested by different administration routes in an S-180 mouse tumor model.
Tumor and immune-cell changes in mice do not establish human treatment efficacy or AP-glucan effects.
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Zou, Siwei; Duan, Bingchao; Xu, Xiaojuan. Inhibition of tumor growth by β-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice. Carbohydrate Polymers. 2019. DOI: 10.1016/j.carbpol.2019.03.006.
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