The effects of β-glucan on human immune and cancer cells
Abstract Non-prescriptional use of medicinal herbs among cancer patients is common around the world. The alleged anti-cancer effects of most herbal extracts are mainly based on studies derived from&nb
Therapeutic potential of various β-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy
Abstract Combined β-glucan with anti-tumor mAb therapy has demonstrated therapeutic efficacy in murine tumor models. The current study was designed to compare the therapeutic efficacy of various sourc
A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy
Abstract β-(1,3)/(1,6) D-glucan, a component of the fungal cell wall, has been shown to stimulate the immune system, enhance hematopoiesis, amplify killing of opsonized tumor cells and increase neutro
Structural characterisation and biological activities of a unique type β-d-glucan obtained from Aureobasidium pullulans
Structural characterisation and biological activities of a unique type β-d-glucan obtained from Aureobasidium pullulans AbstractA β-D-glucan obtained from Aureobasidium pullulans (AP-FB
Anti-tumor metastatic activity of β-glucan purified from mutated Saccharomyces cerevisiae
Abstract The β-glucans isolated from Saccharomyces cerevisiae (S. cerevisiae) enhance the innate immune system, but there is little evidence for its antitumor activity. To examine
Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component
Phagocytosis by Human Neutrophils Is Stimulated by a Unique Fungal Cell Wall Component SummaryInnate immunity depends upon recognition of surface features common to broad groups of pathogens. The gluc
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma
Abstract Despite improvements in chemotherapy and surgery in the treatment of osteosarcoma, satisfactory results are still difficult to achieve. New therapeutic modalities need to be developed for the
Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trialAbstractBackgroundSoluble fibers lower serum lipids, but are dif
Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial
Concentrated oat β-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial AbstractBackgroundSoluble fibers lower serum lipids, but are di
Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer
Abstract Aim Glucans are glucose polymers that constitute a structural part of fungal cell wall. They can stimulate the innate immunity by activation of monocytes/macroph
Immune recognition of fungal beta-glucans
Abstract The recognition of conserved microbial structures is a key aspect of metazoan immunity, and beta-glucans are emerging as a major target for the recognition of fungal pathogens. A number of re
Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model
Abstract Purpose: The Basidiomycete fungus Agaricus blazei Murill has traditionally been used as a health food for the prevention of cancer. Methods: We examined whether beta-(1–6)-D-gl
Fungal β-Glucans and Mammalian Immunity
Fungal β-Glucans and Mammalian Immunity β-Glucans are structural cell wall polymers of many fungi which possess immunomodulatory activities. Although the therapeutic benefits associated with these com
Pneumocystis carinii Cell Wall β-Glucans Initiate Macrophage Inflammatory Responses through NF-κB Activation
Abstract β-Glucans are major structural components of fungi. We have recently reported that the pathogenic fungus Pneumocystis carinii assembles a β-glucan-rich cell wall that potently activ
CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells
Abstract In this report we identify an accessory cell that interacts with primed and memory T cells at sites where they collaborate with B cells. These cells are distinguished from conventional dendri
Immune recognition. A new receptor for beta-glucans
Abstract The carbohydrate polymers known as beta-1,3-d-glucans exert potent effects on the immune system - stimulating antitumour and antimicrobial activity, for example - by binding to receptors on m
Lower concentration of La protein required for internal ribosome entry on hepatitis C virus RNA than on poliovirus RNA
Translation initiation of poliovirus and hepatitis C virus (HCV) RNA occurs by entry of ribosomes to the internal RNA sequence, called the internal ribosomal entry site (IRES). Both IRES bind to the L
Identification of a new element for RNA replication within the internal ribosome entry site of poliovirus RNA.
Several mutants of the Mahoney strain of poliovirus type 1 have been generated by introducing mutations into the stem-loop II (SLII) structure within the internal ribosomal entry site (IRES). Four of
Molecular cloning andexpression of an isomalto-dextranase gene from Anhrobacter globiformis T6
Abstract The gene encoding an extracellular isomalto-dextranase, designated imd, was isolated from the chromosomal DNA of Arthrobacter globiformis T6 and cloned and expressed in Escherichia coli. A si