Antibacterial and antioxidant activities of β-glucans derived from Aureobasidium pullulans
Highlights ●Polysaccharides from A. pullulans were extracted, purified, and characterized. ●PSEX, PSCW, and PSIN were all identified as β-glucans. ●β-Glucans exhibited antibacterial activities against
Beta (β)-glucan as Microbial Polymer with Nutraceutical Potential
Beta (β)-glucan as Microbial Polymer with Nutraceutical Potential Summary Nutraceuticals provide significant potential in enhancing health and mitigating ailments, rendering them a vital inclusion in
Involvement of β-glucan receptors on the antitumor activity of β-glucans
Highlights •β-glucan receptors are closely related to these antitumor effects of β-glucan. •In antitumor immunity, β-glucan is not only effective in simple immune activation. •β-glucan modulates immun
Molecular Interactions of β-(1→3)-Glucans with Their Receptors
Abstract β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(
Potential promising anticancer applications of β-glucans: a review
Potential promising anticancer applications of β-glucans: a review Abstract β-Glucans are valuable functional polysaccharides distributed in nature, especially in the cell walls of fungi, yeasts, bact
Transcriptome Analysis Reveals the Regulation of Aureobasidium pullulans under Different pH Stress
Abstract Aureobasidium pullulans (A. pullulans), a commonly found yeast-like fungus, exhibits adaptability to a wide range of pH environments. However, the specific mechanisms and regulatory path
Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells
Abstract Chondroitin sulfate (CS) is a glycosaminoglycan, and CS derived from various animal species is used in drugs and food supplements to alleviate arthralgia. The CS is a high molecular weight co
5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells
5-Demethylnobiletin is the active ingredient in citrus polymethoxyflavones that could inhibit the proliferation of several tumor cells. However, the anti-tumor effect of 5-Demethylnobiletin on gliobla
Aureobasidium spp.: Diversity, Versatility, and Agricultural Utility
Abstract The black yeast-like fungi Aureobasidium spp. are ubiquitous microorganisms found in a wide variety of extreme and benign environments as saprophytes, endophytes, and pathogens. Sin
PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model
Abstract In the tumor microenvironment (TME), one of the major functions of tumor-recruited CD11b+ cells are the suppression of the T-cell-mediated anti-tumor immune response. β-glucan could conv
Aureobasidium spp. and their applications in biotechnology
Highlights •Aureobasidium spp. can produce much more extracellular enzymes and natural products than any other fungi. •They have rich sources of regulatory elements. •Genome editing techniques for the
β-glucan from Aureobasidium pullulans augments the anti-tumor immune responses through activated tumor-associated dendritic cells
Highlights •AP-BG augments the anti-tumor immune responses. •AP-BG changes the phenotype of TADCs from suppressive to promotive. •AP-BG enhances the production of cytolytic granules and cytokine in th
The effects of oral administration of Aureobasidium pullulans-cultured fluid containing β-glucan on concanavalin A injected mice
Abstract A black yeast, Aureobasidium pullulans, extracellularly produces β-(1,3), (1,6)-D-glucan (β-glucan) under certain conditions. The β-glucan is known to be an immunomodulatory agent, and β
Affinity characteristics of anti-β-(1→3)-d-glucan monoclonal antibody 3G11 by fluorescence polarization immunoassay
Affinity characteristics of anti-β-(1→3)-d-glucan monoclonal antibody 3G11 by fluorescence polarization immunoassay Abstract β-(1→3)-d-Glucan is a branched polysaccharide present in the inner layer of
Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression
Abstract β-Glucans have been studied in animal species, from earthworms to humans. They form a heterogenous group of glucose polymers found in fungi, plants, bacteria, and seaweed. β-Glucans have slow
Biological Activity of High-Purity β-1,3-1,6-Glucan Derived from the Black Yeast Aureobasidium pullulans: A Literature Review
Abstract The black yeast Aureobasidium pullulans produces abundant soluble β-1,3-1,6-glucan—a functional food ingredient with known health benefits. For use as a food material, soluble β-1,3
In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi
Abstract The Japanese larch, (Larix kaempferi) is known to contain abundant taxifolin (dihydroquercetin) in its xylem. In this study, to assess the bioactivities of taxifolin rich methanol extract of&
The effect of Candida cell wall beta-glucan on treatment-resistant LL/2 cancer cell line: in vitro evaluation
Abstract Candida albicans (C. albicans) cell wall beta-glucan has been considered as a potential agent in the treatment of cancers due to its anti-tumor properties. Therefore, in the present stud
Functional activities of beta-glucans in the prevention or treatment of cervical cancer
Abstract Cervical cancer is the fourth-ranked cancer in the world and is associated with a large number of deaths annually. Chemotherapy and radiotherapy are known as the common therapeutic approaches
Cell cytotoxity and anti-glycation activity of taxifolin-rich extract from Japanese larch, Larix kaempferi
Abstract The larches, the Larix genus of plants are known as a natural source of taxifolin (dihydroquercetin), and extracts of its taxifolin rich xylem are used in dietary supplements to mai
Botryosphaeran – A Fungal Exopolysaccharide of the (1→3)(1→6)-β-D-Glucan Kind: Structure and Biological Functions
Botryosphaeran – A Fungal Exopolysaccharide of the (1→3)(1→6)-β-D-Glucan Kind: Structure and Biological Functions AbstractA fungal isolate (MAMB-05) from a stem canker on a eucalypt tree, molecularly
Inhibition of tumor growth by β-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice
Highlights •Oral, intraperitoneal and intratumoral β-glucans inhibited S-180 tumor growth. •β-glucans targeted tumors and interacted with tumor cells. •β-glucans promoted CD4+ T cell differentiation a
Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials
Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials AbstractGlucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as a
Beta-Glucans as a Therapeutic Agent: Literature Review
Potential promising anticancer applications of β-glucans: a review Review ArticleBeta-Glucans as a Therapeutic Agent: Literature ReviewEric Francelino Andrade* and Débora Ribeiro OrlandoInstitute of A