Pro-apoptotic properties of (1,3)(1,4)-β-d-glucan from Avena sativa on human melanoma HTB-140 cells in vitro
Abstract In this study, the growth-inhibitory effect of polysaccharide (1,3)(1,4)-β-d-glucan from oat, Avena sativa L. grains was explored on the human skin melanoma HTB-
Stimulation with the Aureobasidium pullulans-produced β-glucan effectively induces interferon stimulated genes in macrophage-like cell lines
Abstract A β-(1,3),(1,6)-D-glucan produced by A. pullulans (AP-PG) is known to be an immune stimulating agent. In this study, we demonstrate that the stimulation with AP-PG effectively induc
Improved β-glucan yield using an Aureobasidium pullulans M-2 mutant strain in a 200-L pilot scale fermentor targeting industrial mass production
Abstract β-(1→3)-D-glucans with β-(1→6)-glycosidic linked branches are known to be immune activation agents and are incorporated in anti-cancer drugs and health-promoting supplements. β-Glucan concent
Potential of the β-glucans to enhance innate resistance to biological agents
Abstract The use of numerous mushroom species in traditional medicine has been widely documented, with their observed immunomodulatory effects now attributed, in part, to bioactive components called β
Hepatitis C Virus Nonstructural Protein NS3 Binds to Sm-D1, a Small Nuclear Ribonucleoprotein Associated with Autoimmune Disease
Abstract Hepatitis C virus (HCV) causes a persistent infection, chronic hepatitis, and leads to hepatocellular carcinoma. Nonstructural protein 3 (NS3) of HCV possesses protease, nucleoside triphospha
Relevance of signaling molecules for apoptosis induction on influenza A virus replication
Highlights •Apoptosis is an important mechanism to maintain homeostasis. •Infection of influenza A virus induces apoptosis in the virus infected cells. •A large number of signaling molecules are invol
Binding of soluble yeast β-glucan to human neutrophils and monocytes is complement-dependent
The immunomodulatory properties of yeast β-1,3/1,6 glucans are mediated through their ability to be recognized by human innate immune cells. While several studies have investigated binding of opsonize
Improved β-glucan Yield Using an Aureobasidium pullulans M-2 Mutant Strain in a 200-L Pilot Scale Fermentor Targeting Industrial Mass Production
Improved β-glucan yield using an Aureobasidium pullulans M-2 mutant strain in a 200-L pilot scale fermentor targeting industrial mass production Abstractβ-(1→3)-D-glucans with β-(1→6)-glycos
Aureobasidium pullulans culture supernatant significantly stimulates R-848-activated phagocytosis of PMA-induced THP-1 macrophages
Abstract Toll-like receptors (TLRs), which recognize a wide range of microbial pathogens and pathogen-related products, play important roles in innate immunology. Macrophages have a variety of TLRs, a
β-Glucan Derived from Aureobasidium pullulans Is Effective for the Prevention of Influenza in Mice
Abstract β-(1→3)-D-glucans with β-(1→6)-glycosidic linked branches produced by mushrooms, yeast and fungi are known to be an immune activation agent, and are used in anti-cancer drugs or health-promot
Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages
Abstract Recent evidence suggests that the macrophage scavenger receptor class A (SR-A, aka, CD204) plays a role in the induction of innate immune and inflammatory responses. We investigated whether S
Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophage
Abstract Recent evidence suggests that the macrophage scavenger receptor class A (SR-A, aka, CD204) plays a role in the induction of innate immune and inflammatory responses. We investigated whether S
Effect of molecular size and modification pattern on the internalization of water soluble β-(1 → 3)-(1 → 4)-glucan by primary murine macrophages
Abstract It has been shown that β-(1 → 3)-(1 → 4)-glucans (BG34) from barley and oats can trigger recognition and internalization by murine and human macrophages. Increas
A small scale study on the effects of oral administration of the β-glucan produced by Aureobasidium pullulans on milk quality and cytokine expressions of Holstein cows, and on bacterial flora in the intestines of Japanese black calves
Abstract Background The β–(1 → 3),(1 → 6)-D-glucan extracellularly produced by Aureobasidium pullulans exhibits immunomodulatory activity, and is used for health supplements. To examine the
Effect of Water-Soluble Fraction from Lysozyme-Treated Enterococcus faecalis FK-23 on Mortality Caused by Influenza A Virus in Mice
Abstract To maintain homeostasis of the immune system is considered important for the prevention of influenza A virus infection. Aberrant systemic inflammation is frequently induced by influenza A vir
Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population
Abstract Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection. However
Immunomodulatory β-Glucan from Lentinus edodes Activates Mitogen-activated Protein Kinases and Nuclear Factor-κB in Murine RAW 264.7 Macrophages
Lentinan, a cell wall β-glucan from the fruiting bodies of Lentinus edodes, is well known to be a biological defense modifier, but the signal transduction pathway(s) induced by Lentinan have not
Stimulatory Effect of β-glucans on Immune Cells
Abstract β-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infec
Hepatitis C Virus NS3 Protein Can Activate the Notch-Signaling Pathway through Binding to a Transcription Factor, SRCAP
Abstract Persistent infections of hepatitis C virus (HCV) are known to be a major risk factor for causing hepatocellular carcinomas. Nonstructural protein 3 (NS3) of HCV has serine protease and RNA he
Requirement for Siva-1 for replication of influenza A virus through apoptosis induction
Infection with influenza A virus causes acute respiratory tract infections in humans and may lead to lethal diseases including pneumonia. Identifying host factors that are involved in the severity of
Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon Promoter Stimulator 1
Type I interferons (IFNs) are known to be critical factors in the activation of host antiviral responses and are also important in protection from influenza A virus infection. Especially, the RIG-I- a
Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction
Abstract Death associated protein 3 (DAP3) is known to be a highly conserved protein, and is responsible for regulating apoptosis induced by various stimuli. To understand the molecular mechanism of h
Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction Save Related Papers
Abstract Death-associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell&
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation
bstract Detachment of adherent epithelial cells from the extracellular matrix induces apoptosis, a process known as anoikis. We have shown that DAP3 is critical for anoikis induction. However, the mec