This study explores the potential of the endophytic fungus Aureobasidium pullulans AKW for melanin production and its anticancer activity. A. pullulans AKW synthesized 4.89 g/l of melanin in a simple fermentation medium devoid of tyrosine. The isolated melanin exhibited promising selectivity as an anti-cancer agent. It triggered apoptosis in A431 cancer cells, demonstrating selectivity compared to normal cells. The melanin also showed strong antioxidant activity and wound healing potential, making it a multifaceted biomolecule for pharmaceutical applications.
Aureobasidium pullulans AKW produced 4.89 g/L melanin without tyrosine supplementation, suggesting a novel biosynthetic pathway. The purified melanin selectively induced apoptosis in A431 carcinoma cells while sparing normal cells, and additionally demonstrated antioxidant and wound-healing properties, positioning A. pullulans melanin as a multifunctional bioactive compound with broad pharmaceutical potential.
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Elattar KM; Ghoniem AA; Al-Askar AA; El-Gazzar UB; El-Hersh MS; Elsherbiny EA. Melanin Synthesized by the Endophytic Aureobasidium pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity. Current Topics in Medicinal Chemistry. 2024. DOI: 10.2174/0115680266300091240730111333. PMID: 39161142.
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