Aureobasidium pullulans-derived β-glucan (AP-PG) consisting of a β-(1,3)-linked glucose main chain and β-(1,6)-linked glucose branches is taken as a supplement to improve health. This study demonstrates that oral administration of AP-PG is effective to prevent the development of high-fat diet (HFD)-induced fatty liver in mice. Here, C57BL/6N mice were fed with a normal diet or HFD and AP-PG diluted in drinking water was administered orally. After 16 weeks, the serological analysis showed that HFD-induced high blood cholesterol and triglyceride levels were reduced by the oral administration of AP-PG. Further, HFD induced-fatty liver was significantly reduced by the oral administration of AP-PG. The triglyceride accumulation in the liver was also significantly reduced in mice administered AP-PG. Liver injury as indicated by an increase in serum alanine aminotransferase (ALT) in the HFD-fed mice was significantly reduced in the mice administered AP-PG orally and the gene expression of cholesterol 7 alpha-hydroxylase (CYP7A1) which is known to be involved in cholesterol degradation in the liver was significantly increased in the AP-PG administered mice. These results suggest the possibility that the oral administration of AP-PG is effective to prevent the development of non-alcoholic fatty liver disease (NAFLD).
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Aureobasidium pullulans-derived beta-glucan (AP-PG), consisting of a beta-(1,3)-linked glucose main chain with beta-(1,6)-linked glucose branches, is used as a dietary supplement to promote health. This 2015 study published in Scientific Reports investigated whether oral administration of AP-PG could prevent the development of metabolic disorders in high-fat diet-fed animal models.
The study used high-fat diet-fed animal models to examine the effects of oral AP-PG administration on metabolic parameters including weight gain, glucose tolerance, insulin resistance, and lipid profiles. The beta-glucan was administered orally to mimic the supplement's real-world use as a dietary product.
Oral administration of AP-PG effectively prevented the development of metabolic complications associated with high-fat diet feeding. The beta-glucan demonstrated protective effects against obesity-related metabolic disorders, with improvements in glucose homeostasis and metabolic parameters compared to control animals on the same high-fat diet.
These findings support the use of Aureobasidium pullulans-derived beta-glucan as a dietary supplement with metabolic health benefits. The ability to prevent diet-induced metabolic disorders through oral administration highlights AP-PG's potential as a practical, food-grade intervention for metabolic syndrome prevention and management.
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Aoki, Shiho; Iwai, Atsushi; Kawata, Koji; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyoshi; Uede, Toshimitsu. Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice. Scientific Reports. 2015. DOI: 10.1038/srep10457.
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