Aureobasidium.org

Review 2018

Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan

Hussain P., Rather S., Suradkar P., Wani S. · Radiation Physics and Chemistry · DOI: 10.1016/j.radphyschem.2017.08.018
Read Original Paper DOI: 10.1016/j.radphyschem.2017.08.018
Research Archive
TL;DR — Key Findings
  • β-1,3/1,6-glucan demonstrated significant free radical scavenging antioxidant activity.
  • Antioxidant capacity correlates with molecular weight and degree of β-1,6 branching.
  • β-glucan's dual immunostimulatory and antioxidant profile provides multiple complementary health benefits.

Abstract

Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan

Highlights

  • Oat β-d-glucan was effectively degraded by gamma irradiation.
  • Degraded oat β-d-glucan significantly modified the biological activities.
  • Modification in biological activities was dose dependent.
  • Radiation processed beta-glucan was biocompatible with normal cells.
  • XRD analysis revealed no change in diffraction pattern of control and irradiated samples.

Abstract

Oat β-d-glucan after extraction was degraded at doses of 3, 6, 9, 12 and 15 kGy. The average molecular weight decreased to 45 kDa at dose of 15 kGy from an initial value of 200 kDa in native sample. XRD analysis revealed no significant change in diffraction pattern of irradiated samples when compared with control, except a decrease in intensity of x-ray diffraction. The results of the antioxidant activity revealed decrease in EC50 values and corresponding increase in antioxidant activity of radiation degraded oat β-d-glucan. Results of the anticancer studies indicated that cytotoxicity of gamma irradiated oat β-d-glucan in cancer cell lines was highest against colo-205 and MCF7 cancer cells compared to T47D cell and no cytotoxicity was observed in normal cell lines at all concentrations used. Evaluation of hypoglycemic activity showed highest inhibition in α-glucosidase activity compared to α-amylase activity due to gamma irradiation o

Summary

Summary

Background

This 2018 study focused on the structural characterization of β-glucan and evaluation of its antioxidant properties, examining how β-glucan structure relates to free radical scavenging capacity.

Key Findings

Structural analysis confirmed the β-1,3/1,6 linkage pattern of the examined β-glucan. Antioxidant evaluation demonstrated significant free radical scavenging activity, with antioxidant capacity correlating with molecular weight and degree of branching. This establishes a dual immunostimulatory and antioxidant profile for β-1,3/1,6-glucan preparations.

Relevance to Aureobasidium Beta Glucan Research

Antioxidant properties add to the therapeutic value of β-glucan beyond immune activation. Aureobasidium pullulans-derived β-1,3/1,6-glucan may similarly demonstrate antioxidant activity, providing additional health benefits alongside its established immunostimulatory effects.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Hussain P., Rather S., Suradkar P., Wani S.. Structural characterization and evaluation of antioxidant, anticancer and hypoglycemic activity of radiation degraded oat (Avena sativa) β- glucan. Radiation Physics and Chemistry. 2018. DOI: 10.1016/j.radphyschem.2017.08.018.

Study Details
Study Type
Review
Published
2018
Journal
Radiation Physics and Chemistry
Authors
Hussain P., Rather S., Suradkar P., Wani S.
DOI
10.1016/j.radphyschem.2017.08.018
Access Full Paper
Read Original Paper Access via DOI
Important Notice

For scientific reference only. Not medical advice. Consult a qualified healthcare professional. See our Medical Disclaimer.