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In Vivo 2015

Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

Aoki, Shiho; Iwai, Atsushi; Kawata, Koji; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyoshi; Uede, Toshimitsu · Journal of Functional Foods · DOI: 10.1016/j.jff.2015.06.044
Read Original Paper DOI: 10.1016/j.jff.2015.06.044
Research Archive
TL;DR — Key Findings
  • Oral AP-beta-glucan was tested in high-fat-diet-fed ApoE-deficient mice.
  • Treated mice showed less plaque, lower oxidized LDL, and less vascular macrophage accumulation.
  • The study does not establish cardiovascular prevention or treatment in humans.

Abstract

This animal study tested oral Aureobasidium pullulans-produced beta-glucan in apolipoprotein-E-deficient mice fed a high-fat diet. Compared with untreated controls, treated mice developed less atherosclerotic plaque, had lower oxidized-LDL measurements, and showed less macrophage accumulation in blood vessels. These observations suggest a possible effect in this experimental model. The study does not show simultaneous activation of macrophages, natural-killer cells, and dendritic cells, and it does not establish prevention or treatment of cardiovascular disease in humans.

Summary

Summary

Study design

AP-beta-glucan was given orally to ApoE-deficient mice in a high-fat-diet atherosclerosis model.

Interpretation

Plaque, oxidized LDL, and vascular macrophage measures improved in mice. Human cardiovascular benefit was not tested.

AI-generated summary for accessibility. Always refer to the original paper.

Citation

Aoki, Shiho; Iwai, Atsushi; Kawata, Koji; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyoshi; Uede, Toshimitsu. Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice. Journal of Functional Foods. 2015. DOI: 10.1016/j.jff.2015.06.044.

Study Details
Study Type
In Vivo
Published
2015
Journal
Journal of Functional Foods
Authors
Aoki, Shiho; Iwai, Atsushi; Kawata, Koji; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyoshi; Uede, Toshimitsu
DOI
10.1016/j.jff.2015.06.044
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