Several biological activities of the fungal exopolysaccharide (1→3)(1→6)-β-d-glucan (botryosphaeran) have been described, but its effects on inflammation had not been evaluated. This study investigated botryosphaeran in experimental mice models of carrageenan-induced acute pleurisy, acute paw edema, and complete Freund's adjuvant-induced persistent paw edema. All botryosphaeran doses tested (1.0, 2.5, 5.0, and 10.0 mg/kg) reduced leukocyte recruitment, nitric oxide levels, and protein extravasation in the pleural cavity. The study demonstrated the anti-inflammatory and antinociceptive potential of botryosphaeran, making this fungal β-glucan a new possibility for complementary treatment of acute and chronic inflammation.
Botryosphaeran is a fungal exopolysaccharide with β-(1→3) and β-(1→6) glucan linkages, produced by the ascomycete Botryosphaeria rhodina. This review examined its structural properties and biological activities.
Botryosphaeran shares structural features with other biologically active β-1,3/1,6-glucans and demonstrates immunostimulatory, antioxidant, and potential anti-tumor properties. Structure-activity analysis revealed that its branched β-glucan backbone engages similar pattern recognition receptors as other immunomodulatory glucans.
Botryosphaeran's β-1,3/1,6 structure closely parallels that of Aureobasidium pullulans-derived β-glucan. Comparative study of these fungal exopolysaccharides strengthens the structural basis for AP-glucan immunomodulation and provides additional reference data for AP-glucan biological activity prediction.
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Silva, Nubia A; Pereira, Bianca G; Santos, Joyce A; Guarnier, Flávia A; Barbosa-Dekker, Aneli M; Dekker, Robert F H; Kassuya, Cândida A L; Bernardes, Sara S. Oral administration of botryosphaeran [(1 → 3)(1 → 6)‐β‐d‐glucan] reduces inflammation through modulation of leukocytes and has limited effect on inflammatory nociception. Cell Biochemistry and Function. 2022. DOI: 10.1002/cbf.3727. PMID: 35788958.
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