Cytokine production enhancing compositions in macrophages – U.S. (U.S. Patent No. US8,802,433)
Patent Details
Country of RegistrationUSA
Patent No.No. US8,802,433Registration DateAugust 12, 2014
The combination of Aureo culture medium and leciquimod, a compound with antiviral activity, has been proven to synergistically activate macrophages, and a new immunostimulatory effect of Aureo culture medium has been recognized.When activated, macrophages, a type of immune cell, processed cancer cells and cells damaged or killed by anticancer drugs through phagocytosis, and further activated them to produce physiologically active substances called cytokines, thereby enhancing immunity.※ Reciquimod has antiviral and antitumor activity.
This Japanese patent covers compositions for enhancing cytokine production in macrophages using Aureobasidium pullulans-derived β-glucan, protecting formulations designed to boost innate immune signaling.
The patent claims specific β-glucan formulations that enhance macrophage cytokine production, building on established evidence for AP-glucan macrophage activation. Patent protection reflects proprietary optimization of AP-glucan delivery for maximal macrophage stimulation.
Patent protection for cytokine-enhancing AP-glucan formulations demonstrates commercial development of immunostimulatory applications. These patents represent decades of research investment translated into protected intellectual property around Aureobasidium pullulans β-glucan's immune activation properties.
Uchiyama H., Iwai A., Nagahara Y.. Cytokine production enhancing compositions in macrophages – U.S. (U.S. Patent No. US8,802,433). Japanese Patent Office. 2023.
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