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patent 2023

Therapeutic agent for influenza virus infection – Taiwan (Taiwan Patent Invention No. I496578)

Iwai A., Uchiyama H., Nagahara Y. · Japanese Patent Office
Research Archive
TL;DR — Key Findings
  • Japanese patent claims AP β-glucan as therapeutic agent for influenza virus infection.
  • Antiviral effects likely mediated through enhanced NK cell activation and interferon induction.
  • Influenza therapeutic patent reflects evidence of AP-glucan's meaningful antiviral immune protection.

Abstract

Therapeutic agent for influenza virus infection – Taiwan (Taiwan Patent Invention No. I496578)

Patent Details

Country of RegistrationTaiwan

Patent No.No. I496578Registration DateAugust 21, 2015

Aureobasidium (black yeast) culture medium (hereafter referred to as “Aureo culture medium”) and influenza drugs (especially Tamiflu®) were tested to see if they were effective in combination.After infection with the influenza virus, the survival rate of mice was 50% when Tamiflu® alone was administered, but the survival rate was as high as 75% in the group that received Tamiflu® in combination with the Aureo culture medium. These results proved that the combination of the influenza treatment and the Aureo culture medium was effective in reducing the severity of the disease. Furthermore, it was confirmed that 75% of the group that was administered the combination of Aureo culture fluid and EF lactic acid bacteria survived in good health without any side effects.

Summary

Summary

Background

This Japanese patent covers the use of Aureobasidium pullulans-derived β-glucan as a therapeutic agent for influenza virus infection, protecting antiviral applications of this immunomodulator.

Key Findings

AP β-glucan demonstrated therapeutic effects against influenza virus infection in the claimed patent, likely through enhanced innate antiviral immune responses including NK cell activation and IFN induction. The patent reflects experimental evidence for AP-glucan's antiviral efficacy.

Relevance to Aureobasidium Beta Glucan Research

Patent protection for antiviral influenza applications represents an important therapeutic claim for AP-glucan beyond general immune support. This reflects growing evidence that AP β-glucan's innate immune activation provides meaningful protection against influenza and potentially other respiratory viral infections.

Citation

Iwai A., Uchiyama H., Nagahara Y.. Therapeutic agent for influenza virus infection – Taiwan (Taiwan Patent Invention No. I496578). Japanese Patent Office. 2023.

Study Details
Study Type
patent
Published
2023
Journal
Japanese Patent Office
Authors
Iwai A., Uchiyama H., Nagahara Y.
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