Probes for observation of intestinal post-absorptive kinetics using beta-1,3-1,6 glucan labeled with stable isotope 2H and/or stable isotope 13C – Japan (Patent No. 5360849)
Patent Details
Country of RegistrationJapan
Patent No.No. 5360849Registration DateSeptember 13, 2013
Theoretically, β-glucan is absorbed through the intestinal tract and comes into contact with immune cells, but it has been difficult to demonstrate that high molecular weight β-glucan is absorbed through the intestinal tract.Aureo has succeeded in proving that β-glucan is absorbed into the Peyer’s patented method using a stable isotope microscope, an advanced measuring instrument used for research on the asteroid probe “Hayabusa”.
This Japanese patent covers probe compositions using Aureobasidium pullulans-derived β-glucan for observation of intestinal post-absorptive processes, reflecting the diversity of AP-glucan applications.
AP β-glucan was developed as a probe compound for studying intestinal absorption and post-absorptive distribution processes, leveraging its structural characteristics for tracking studies. This application utilizes β-glucan's biological stability and detectability properties.
Research tools using AP-glucan for intestinal absorption studies contribute to understanding the pharmacokinetics of oral β-glucan supplementation. These probe studies help characterize how AP-glucan is absorbed and distributed following oral administration.
Uchiyama H., Iwai A., Nagahara Y.. Probes for observation of intestinal post-absorptive kinetics using beta-1,3-1,6 glucan labeled with stable isotope 2H and/or stable isotope 13C – Japan (Patent No. 5360849). Japanese Patent Office. 2023.
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