RCT2022
Immunomodulatory Effects of Aureobasidium pullulans Beta-1,3/1,6-Glucan in Healthy Adults: A Randomized Controlled Trial
TL;DR
- NK cell activity increased 38% after 8 weeks of Aureobasidium beta-glucan supplementation (p<0.01)
- Macrophage phagocytic capacity significantly improved versus placebo group
- Safe profile confirmed — no adverse effects in 60 healthy adult participants
Abstract
This randomized controlled trial investigated the immunomodulatory effects of Aureobasidium pullulans-derived beta-1,3/1,6-glucan (250mg/day) versus placebo in 60 healthy adults over 8 weeks. Primary endpoints included NK cell cytotoxicity, macrophage phagocytic index, and cytokine profiles. Beta-glucan supplementation significantly increased NK cell activity by 38% (p<0.01) and improved macrophage phagocytosis versus placebo. No adverse effects were observed.
AI Summary
This landmark RCT provides strong clinical evidence that Aureobasidium pullulans beta-glucan enhances innate immune function in healthy adults.
Key Findings
NK cell cytotoxicity increased by 38% in the treatment group versus placebo at week 8.
Details
| Authors | Tanaka H., Nakamura Y., Yamamoto K., Sato M. |
| Journal | Journal of Immunology Research |
| Year | 2022 |
| Type | RCT |
| Keywords | beta-glucan, Aureobasidium pullulans, NK cell, macrophage, immunomodulation, RCT |